- Association Between Gamma-Glutamyltransferase and Hypertension Incidence in Rural Prehypertensive Adults.
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Jun Hyun Hwang, Ji Yeon Shin, Byung yeol Chun, Duk Hee Lee, Keon Yeop Kim, Wee hyun Park, Shung chull Chae
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J Prev Med Public Health. 2010;43(1):18-25.
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DOI: https://doi.org/10.3961/jpmph.2010.43.1.18
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- OBJECTIVES
Prehypertension is associated with a higher risk of developing hypertension compared with normotension. Yet, factors predicting the development of hypertension among prehypertensive people are ill-understood. This prospective cohort study was performed to examine if serum gamma-glutamyltrasferase (GGT) within a normal range can predict the future risk of hypertension among prehypertensive adults. METHODS: Study subjects were 293 prehypertensive persons >30-years-of-age who participated in a community-based health survey in 2003 and who were followed up in 2008. Sex-specific quartiles of baseline serum GGT were used to examine association with 5-year hypertension incidence. RESULTS: Baseline serum GGT within normal range predicted the risk of developing hypertension for 5 years only in prehypertensive women. Adjusted relative risks were 1.0, 3.7, 3.6, and 6.0 according to quartiles of baseline serum GGT (P for trend <0.01). This pattern was similarly observed in non-drinkers. However, serum GGT was not associated with incident hypertension in men. Different from serum GGT, baseline serum alanine aminotransferase, another well-known liver enzyme, did not predict the risk of incident hypertension in both genders. CONCLUSIONS: Even though baseline serum GGT within normal range strongly predicted the future risk of hypertension, it was observed only in women, Although underlying mechanisms of this association are currently unclear, serum GGT can be used to select a high risk group of hypertension in prehypertensive women.
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Citations
Citations to this article as recorded by  - Gamma-glutamyltransferase and risk of hypertension
Setor K. Kunutsor, Tanefa A. Apekey, Bernard M.Y. Cheung
Journal of Hypertension.2015; 33(12): 2373. CrossRef - Endobiogeny: A Global Approach to Systems Biology (Part 1 of 2)
Jean-Claude, Lapraz, Kamyar M. Hedayat
Global Advances in Health and Medicine.2013; 2(1): 64. CrossRef - Gamma-Glutamyltransferase Level and Risk of Hypertension: A Systematic Review and Meta-Analysis
Cun-Fei Liu, Yu-Ting Gu, Hai-Ya Wang, Ning-Yuan Fang, Antony Bayer
PLoS ONE.2012; 7(11): e48878. CrossRef - Association between γ-glutamyltransferase and prehypertension
XUZHEN QIN, GUODONG TANG, LING QIU, TAO XU, XINQI CHENG, SHAOMEI HAN, GUANGJIN ZHU, YAJUN LIU
Molecular Medicine Reports.2012; 5(4): 1092. CrossRef
- The Incidence Rate of Coronary Heart Disease in City Area.
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Byung Yeol Chun, Kwon Bae Kim, Kee Sik Kim, Young Jo Kim, Yoon Nyun Kim, Chang Yoon Kim, Wee Hyun Park, Dong Gu Shin, Bong Sub Shin, Jong Joo Lee, Choong Won Lee, Sung Gug Chang, Jae Eun Jun, Yong Keun Cho, Shung Chuil Chae, Gi Yong Choi, Young Ae Ha, Young Sook Lee
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Korean J Prev Med. 1998;31(3):395-403.
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Abstract
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- To estimate the incidence rate of coronary heart disease in Korea, of all residents of the Taegu city aged 25 or above, those who had an acute MI or fatal coronary event between 1 July 1996 and 30 June 1997 were registered. Seven hundreds and eight patients were registered during the study period(685 were identified at hospital and 23 were autopsy cases). Age-standardized annual incidence rate of men in city area was 93 per 100,000(95% CI; 61-142) and 33(95% CI; 16-67) in women(100 in men and 20 in women aged 35-64). The incidence was rapidly increased after age 40 in men, however, in women after age 60. Twenty-eight-days case fatality rate was 45% in men and 47% in women. However, in the age group of 45-59 case fatality rate in women was two times higher than that in men. In conclusion, crude annual incidence rate of CHD in city area was 73 per 100,000 in men and 33 in women. The age-standardized annual incidence of CHD in men(93 per 100,000) was 3.2 times higher than that in women (33 per 100,000) in Korea.
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